Clinical Guidance Reviewed by Board-Certified Anesthesiologists & Psychiatrists

DEA Schedule III Clinical Protocols • Review Board & Editorial Policy

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Verified Ketamine Infusion Clinics, Without the Guesswork.

Compare board-certified medical directors, IV vs. Spravato® esketamine protocols, transparent out-of-pocket costs, and patient outcomes across 50 states.

Popular Metros: Austin, TX Los Angeles, CA Miami, FL Browse all 50 states →

The Four Pillars of Clinical Ketamine Care

What every prospective patient must examine before selecting an infusion center.

Physician-Led Oversight

Verify whether your infusions are actively supervised on-site by a Board-Certified Anesthesiologist (MD/DO) or Psychiatric specialist with cardiac and vitals monitoring.

Continuous ECG & Pulse Oximetry Required

IV Infusion vs. Spravato®

Intravenous (IV) ketamine provides 100% immediate bioavailability with precision dose titration. Spravato (esketamine) is FDA-approved with REMS certified insurance coverage.

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Pricing & Superbills

Most IV infusion clinics charge between $375 and $550 per psychiatric infusion. We track which clinics provide compliant CMS Superbills for out-of-network reimbursement.

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Verified Clinical Providers

Featured Ketamine Centers

Pre-screened for clinical supervision, certified facilities, and transparent pricing.

Verified Provider Austin, TX

Austin Ketamine & Wellness Clinic

Medical Director: Robert Miller, MD (Board Certified Anesthesiologist)

IV Ketamine Infusion Spravato REMS Superbill Provided

Psychiatric Protocol: $425 / infusion

Initial Series: 6 Sessions ($2,550)

Rating: ★ 4.9 (62 Patient Reviews)

Verified Provider Los Angeles, CA

Pacific Mind Infusion Center

Medical Director: Sarah Lin, MD (Psychiatry & Interventional Care)

IV Ketamine Chronic Pain Protocol Integration Therapy

Psychiatric Protocol: $450 / infusion

Pain Infusion (4h): $850 / session

Rating: ★ 4.8 (48 Reviews)

Verified Provider Miami, FL

Biscayne Interventional Psychiatry

Lead Provider: Elena Vasquez, MD & CRNA Team

Spravato REMS Center IV Ketamine Insurance Accepted

Spravato: Covered by Major Insurers

IV Infusion: $395 / infusion

Rating: ★ 5.0 (39 Reviews)

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Patient Guidance

Frequently Asked Questions

How much does a ketamine infusion series typically cost in the US?

In the United States, an individual psychiatric IV infusion typically costs between $350 and $600. A standard induction protocol involves 6 infusions over 2 to 3 weeks, totaling roughly $2,100 to $3,600. Chronic pain infusions require higher doses and longer durations (3–4 hours) and typically range from $700 to $1,500 per session.

Does health insurance cover IV ketamine infusions?

IV ketamine is currently an FDA-approved anesthetic prescribed "off-label" for depression and PTSD; therefore, private insurers rarely cover the infusion medication directly. However, some insurance plans reimburse associated consultation or monitoring codes (e.g., CPT 99214, 96365). Alternatively, Spravato® (esketamine nasal spray) is FDA-approved for Treatment-Resistant Depression and is covered by most major commercial insurers and Medicare.

Who should supervise a ketamine infusion?

Best practice guidelines established by the American Society of Anesthesiologists (ASA) and the American Psychiatric Association (APA) recommend that infusion clinics have an on-site physician (MD or DO) trained in cardiac life support (ACLS) or a Certified Registered Nurse Anesthetist (CRNA) under direct medical supervision, with continuous heart rate, blood pressure, and oxygen saturation monitoring.